ScyllaHide is an advanced open-source x64/x86 usermode Anti-Anti-Debug library. It hooks various functions in usermode to hide debugging. This tool is intended to stay in usermode (ring3). If you need kernelmode (ring0) Anti-Anti-Debug please see TitanHide https://github.com/mrexodia/titanhide.
ScyllaHide supports various debuggers with plugins: